SKIN PENETRATION OF KETOCAINE
نویسندگان
چکیده
منابع مشابه
Pathways for Skin Penetration
This paper reviews recent fi ndings about three skin penetration pathways (including a “polar pathway”) and four types of penetration enhancers (enzymes, vesicular systems, ceramides and chemical enhancers). This article will review possible ways for compounds to penetrate the skin and interact with it. Four families of enhancers will be discussed, along with their possible mechanisms of action...
متن کاملAllergen penetration through the skin.
The skin is directly in contact with environmental molecules which are present in the air or directly in contact with the epidermis. Despite the assumption that it has a barrier role which could prevent the penetration of molecules, the skin is permeable to all substances from the low molecular weight xenobiotics to the high molecular weight proteins. Only the degree of permeability varies depe...
متن کاملStrategies for Skin Penetration Enhancement
Dermatological and cosmetic preparations frequently contain active principles which can only act when they penetrate at least the outermost layer of the skin. However, the efficacy of topically applied actives is often suboptimal because the transport into the skin is slow due to the resistance of the outermost layer of the skin, the stratum corneum. Most small water-soluble nonelectrolytes the...
متن کاملPenetration of chlorhexidine into human skin.
This study evaluated a model of skin permeation to determine the depth of delivery of chlorhexidine into full-thickness excised human skin following topical application of 2% (wt/vol) aqueous chlorhexidine digluconate. Skin permeation studies were performed on full-thickness human skin using Franz diffusion cells with exposure to chlorhexidine for 2 min, 30 min, and 24 h. The concentration of c...
متن کاملQSAR Analyses of Skin Penetration Enhancers
QSAR models for four skin penetration enhancer data sets of 61, 44, 42, and 17 compounds were constructed using classic QSAR descriptors and 4D-fingerprints. Three data sets involved skin penetration enhancement of hydrocortisone and hydrocortisone acetate. The other data set involved skin penetration enhancement of fluorouracil. The measure of penetration enhancement is the ratio of the net pe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1979
ISSN: 0007-0912
DOI: 10.1093/bja/51.12.1189-a